In Vitro Anticancer Activity of Hexane and Ethyl acetate Extracts of Leaf, Petiole and Rhizome of Petasites japonicus

The aim of this study was to ascertain the effect different solvents on extraction yield, antioxidant activity and cytotoxicity extracts from Petasites japonicus (Siebold & Zucc.) Maxim. P. japonicus, widely distributed in Korea, Japan China, is used as a culinary vegetable traditional medicine for asthma, migraines tension headaches, allergic rhinitis. In study, twelve leaves, petioles rhizomes were evaluated their antiproliferative against AGS, HepG2, HCT-116, MCF-7 cancer cell lines. Plant fractionated using hexane, EtOAc, BuOH distilled water, after which measured by MTT assay. Cell viability decreased dose dependent manner response hexane ethyl acetate all lines, with significant decrease being observed 100 μg/ml 75 AGS HepG2 lines (p < 0.05). leaf extract appeared be more potent indicated IC50 values 4.31 approximately 2.5- 6.3-fold compared rhizome petiole extracts, respectively. leaves and rhizomes human greater than those other while showed higher Hexane EtOAc exerted four Overall, results indicate that has potential developed into selective anticancer nutraceutical and/or pharmaceutical treatments low cost.